Rev. Saúde Pública 2005;18(2):138-154
The evolution of immunoglobulins involved in the immune response to mice infected with Schistosoma mansoni
DOI: 10.1590/S0034-89101984000200006
The evolution of immunoglobulins involved in the immune response of mice infected with Schistosoma mansoni was studied by using plurispecific sera and the bi-dimensional immunoelectrophoresis technique. Determinations of the level of different immunoglobulins in infected animals and control groups which were mantained under similar conditions detected significant variations in both groups over the 8 weeks of observation. The study of the relationship (I/C) between the level of immunoglobulins of the infected animals (I) and that of corresponding control (C) showed that the infected animals presented a primary response (1-2 weeks after infection date) and a secondary response that was initiated in the 6th week of infection, with levels of IgA, IgG and IgM that were respectively 4.5, 3 and 2 times higher than those of corresponding control.
Keywords: Schistosoma mansoni; Immunoglobulins; Schistosomiasis
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