A reduced schedule for a pre-exposure anti-rabic immunization, of humans with 3 doses of 1 ml of Fuenzalida-Palacios type vaccine administered on alternate days, plus one booster 30 days after the first dose, was related. The blood samples were collected on the 0, 30th and 40th day after the first vaccine dose and the antibody titration was performed by serum neutralizing test. It was observed that 74,6% of the patients presented serum neutralizing antibodies on the 30th day and 98.1% […]

ERA anti-rabies vaccine prepared in kidney tissue culture was evaluated against four different antigenic strains of rabies virus in mice: two of them dog strains, C/SP and C/NG, another a bat vampire strain, DR-19, and the CVS strain. The CVS antigenical characteristics were determined by means the antinucleocapsid monoclonal antibodies technique. Twenty one days old mice were vaccinated, intramuscularly, in the inner side of the thigh, with 0.05 ml of vaccine and challenged at 42 days old, together with those […]

Protection levels of an attenuated antirabies vaccine, of ERA origin, prepared in Kidney tissue culture, were evaluated in mice. Two schemes of vaccination were utilized: a single dose and 6 doses on alternate days. Animals of different experimental groups were challenged at 15, 30, 60 and 120 days post-immunization with six antigenic variants of rabies virus: strains of dog origin (S. Paulo, Brazil and Nigéria), vampire origin (DR-19 and Pernambuco, Brazil), fox origin (Rio Grande do Norte,Brazil), and CVS (Challenge […]

Recent advances in research into rabies, based on the technological process of the biological sciences mainly molecular biology and genetic engineering, are mentioned. The current knowledge of the characteristics, properties pathogeny and immunology of the rabies views is presented, as well as the development of new diagnostic and vaccine evaluation techniques. The epidemiological importance of the identification of different immunogenic rabies virus strains and the role in immunoprophylaxis of the production of highly immunogenic vaccines, are set out.

A historical review of the treatment of human rabies from ancient times up to the present is undertaken. An attempt is made to trace parallel between the concept of the main cause of rabies in a certain period and the kind of treatment utilized. The ancient Greek goddess Artemis was considered to be a healer of rabies; they already identified wound cauterization. People of the first century A.D. knew of the infection deriving from the saliva of a rabid dog […]

INTRODUCTION: An anti-rabies campaign is undertaken annually in Brazil with of the Fuenzalida & Palacios vaccine. The humoral immune response of dogs vaccinated during the campaigns was researched with the objective of evaluating whether the dogs presented a protective titer (0.5 UI/ml) 12 months after vaccination and how many of these achieved this titer 30 days after a buttressing vaccination. MATERIAL AND METHOD: Three hundred and forty-one specimens of serum of dogs domicilied, 259 in the S. Paulo and 82 […]